Stage 4S Bilateral Adrenal Neuroblastoma in a Newborn
نویسندگان
چکیده
Stage 4S bilateral adrenal neuroblastoma presenting in the neonatal period is extremely rare. A 1-day-old male with 4Sbilateral adrenal neuroblastoma complicated by marked hepatomegaly managed by chemotherapy is being reported. The provisional diagnosis of neuroblastoma was made in the fetal life during the last trimester of pregnancy. Cardiomyopathy due to doxorubicin cytotoxicity developed over ensuing years, which is being treated.
منابع مشابه
Management of stage 4S composite neuroblastoma with a MYCN-amplified nodule.
MYCN amplification in neuroblastoma is usually associated with a poor prognosis. Very few cases of heterogenous MYCN amplification have been previously reported, and the clinical significance of heterogeneity is unclear. We report a neonate with an adrenal stage 4S neuroblastoma with a small focus of MYCN-amplified cells within a nonamplified background. After adrenalectomy, the patient has bee...
متن کاملMetastatic neuroblastoma to the mandible in a 3-year-old boy: a case report.
Although neuroblastoma is a relatively common malignancy of childhood and its dissemination to distant organs is often seen, metastasis to the mandible is rare. A 3-year-old boy which a mandibular soft tissue mass was the initial presenting symptom of disseminated neuroblastoma is reported. The results of biopsy were inconclusive and the differential diagnosis from the imaging studies included ...
متن کاملModulatory effect of the sympathetic nervous system on neuroblastoma tumor growth.
Growth of C-1300 neuroblastoma was markedly suppressed in mice chemically sympathectomized at birth with 6-hydroxydopamine. Growth of A-10 adenocarcinoma was also somewhat reduced. In newborn mice pretreated with nerve growth factor to induce sympathetic nervous system neuronal hypertrophy, neuronal maturation, and peripheral hyperinnervation, the growth of neuroblastoma was augmented.
متن کاملParatesticular Neuroblastoma Presenting as Bilateral Paratesticular Tumors
We describe a case of simultaneous bilateral paratesticular neuroblastoma presenting as spermatic cord tumors in a 6-month-old boy. He was diagnosed as having stage IV neuroblastoma originated from right adrenal gland with metastases to the paratesticular region, right femur, and right maxilla. The tumor showed favorable biological features according to Shimada’s classification and had no N-myc...
متن کاملPrimary Intrarenal Neuroblastoma with Hypertension and Disseminated Intravascular Coagulation
The primary intrarenal neuroblastoma (IRNB) is a rare condition. Intrarenal neuroblastoma typically results from direct renal invasion from an adrenal neuroblastoma, but true intrarenal neuroblastoma originates either sequestered adrenal rests during the fetal life or intrarenal sympathetic ganglia. Clinical, radiological, and pathological correlation is very essential for diagnosis and appropr...
متن کامل